Reduced Jet Velocity in Venous Flow after CSF Drainage: Assessing Hemodynamic Causes of Pulsatile Tinnitus

• Published in: American journal of neuroradiology : AJNR Vol. 40; no. 5; pp. 849 - 854
• Main Authors: Haraldsson, H, Leach, J R, Kao, E I, Wright, A G, Ammanuel, S G, Khangura, R S, Ballweber, M K, Chin, C T, Shah, V N, Meisel, K, Saloner, D A, Amans, M R
• Format: Journal Article
• Language: English
• Published: United States American Society of Neuroradiology 01-05-2019
• Subjects: Adult; Cerebrovascular Circulation - physiology; Constriction, Pathologic - complications; Constriction, Pathologic - pathology; Female; Head & Neck; Hemodynamics - physiology; Humans; Male; Middle Aged; Pseudotumor Cerebri - complications; Pseudotumor Cerebri - physiopathology; Pseudotumor Cerebri - surgery; Spinal Puncture - methods; Tinnitus - etiology; Tinnitus - physiopathology; Tinnitus - surgery; Transverse Sinuses - pathology; Transverse Sinuses - physiopathology
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A6043

Idiopathic intracranial hypertension is commonly associated with transverse sinus stenosis, a venous cause of pulsatile tinnitus. In patients with idiopathic intracranial hypertension, CSF drainage via lumbar puncture decreases intracranial pressure, which relieves the stenosis, and may provide at least temporary cessation of pulsatile tinnitus. The objective of this study was to evaluate changes in venous blood flow caused by lowered intracranial pressure in patients with pulsatile tinnitus to help identify the cause of pulsatile tinnitus.
Ten patients with suspected transverse sinus stenosis as a venous etiology for pulsatile tinnitus symptoms underwent MR imaging before and after lumbar puncture in the same session. The protocol included flow assessment and rating of pulsatile tinnitus intensity before and after lumbar puncture and MR venography before lumbar puncture. Post-lumbar puncture MR venography was performed in 1 subject.
There was a lumbar puncture-induced reduction in venous peak velocity that correlated with the opening pressure (
= -0.72,
= .019) without a concomitant reduction in flow rate. Patients with flow jets had their peak velocity reduced by 0.30 ± 0.18 m/s (
= .002), correlating with a reduction in CSF pressure (
= 0.82,
= .024) and the reduction in subjectively scored pulsatile tinnitus intensity (
= 0.78,
= .023). The post-lumbar puncture MR venography demonstrated alleviation of the stenosis.
Our results show a lumbar puncture-induced reduction in venous peak velocity without a concomitant reduction in flow rate. We hypothesize that the reduction is caused by the expansion of the stenosis after lumbar puncture. Our results further show a correlation between the peak velocity and pulsatile tinnitus intensity, suggesting the flow jet to be instrumental in the development of sound.