Some Effects of Dietary Fat Upon Steroid and Amino Acid Metabolism

Ten normal adult men were maintained on a diet relatively high in saturated fats and low in polyunsaturated fats for eleven days, and then for twenty-one days on a diet in which the ratio of saturated to unsaturated fat was reversed. The following changes were observed after the second diet, as comp...

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Bibliographic Details
Published in:	The American journal of clinical nutrition Vol. 16; no. 2; pp. 232 - 237
Main Authors:	MELLINKOFF, SHERMAN M., FRANKLAND, MARJORIE, SCHWABE, ARTHUR D., KELLNER, HEINZ C., GREIPEL, MARGARET, MCNALL, DOROTHY
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-02-1965
Subjects:	17-Ketosteroids Amino Acids - metabolism Anabolic Agents Androgens Biomedical Research Blood Proteins Cholesterol - blood Dietary Fats Fats, Unsaturated Humans Lipid Metabolism Lipids - blood Old Medline Steroids Urine BLOOD LIPIDS BLOOD PROTEINS CLINICAL RESEARCH BLOOD CHOLESTEROL ANABOLIC STEROIDS FATS, UNSATURATED DIETARY FATS LIPID METABOLISM AMINO ACIDS URINE 17-KETOSTEROIDS AMINO ACID METABOLISM ANDROGENS
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Summary:	Ten normal adult men were maintained on a diet relatively high in saturated fats and low in polyunsaturated fats for eleven days, and then for twenty-one days on a diet in which the ratio of saturated to unsaturated fat was reversed. The following changes were observed after the second diet, as compared with similar values after the first: a decrease in the plasma concentrations of cholesterol, total lipids, leucine and valine, and an increase in proline, cystine, arginine, 3-methylhistidine and aspartic acid; diminished urinary excretion of total neutral 17-oxosteroids as determined by acid hydrolysis and diminished urinary excretion of total 11-desoxy-17-oxosteroid fractions; diminished urinary excretion of etiocholanolone, cystine, valine, 3-methylhistidine and β-alanine with increased urinary excretion of anserine, cystathionine and 1-methylhistidine. No consistent corresponding changes were observed in the urinary fractions of dehydroepiandrosterone, androsterone, amino acids other than those mentioned, or in the plasma levels of the dehydroepiandrosterone and androsterone conjugates or free dehydroepiandrosterone, androsterone and etiocholanolone.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9165 1938-3207
DOI:	10.1093/ajcn/16.2.232