The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniae

• Published in: Journal of antimicrobial chemotherapy Vol. 50; no. suppl-3; pp. 1 - 6
• Main Author: KLUGMAN, Keith P
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Oxford University Press 01-12-2002; Oxford Publishing Limited (England)
• Subjects: Animals; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Clone Cells - drug effects; Clone Cells - physiology; Drug Resistance, Bacterial - genetics; Fluoroquinolones; Genetic Vectors - genetics; Humans; Medical sciences; Pharmacology. Drug treatments; Point Mutation - drug effects; Point Mutation - genetics; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - genetics; β-Lactams; Streptococcus pneumoniae; Tetracycline; Resistance; Streptococcaceae; Antibiotic; Cephalosporin derivatives; Fluoroquinolone derivatives; Bacteria; Micrococcales; Mutation; Antibacterial agent; Quinolone derivatives
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkf500

A small number of pneumococcal clones dominate the population of antibiotic-resistant pneumococci. The emergence of fluoroquinolone resistance in these clones predicts the dissemination of fluoroquinolone resistance in countries where the clones are present and community use of fluoroquinolones for respiratory infections is common. The molecular basis of resistance to a number of classes of antimicrobials can be used to predict the likelihood of dissemination of the resistance genes.