Neurotrophins and Their Receptors: BDNF's Role in GABAergic Neurodevelopment and Disease

• Published in: International journal of molecular sciences Vol. 25; no. 15; p. 8312
• Main Authors: Hernández-Del Caño, Carlos, Varela-Andrés, Natalia, Cebrián-León, Alejandro, Deogracias, Rubén
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-08-2024
• Subjects: Animals; autism; BDNF; Brain - growth & development; Brain - metabolism; Brain research; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Canada; Chromosomes; Diseases; GABA; GABAergic neurons; GABAergic Neurons - metabolism; Humans; Hypothalamus; Mental disorders; Nerve Growth Factors - genetics; Nerve Growth Factors - metabolism; neurodevelopment; Neurodevelopmental Disorders - genetics; Neurodevelopmental Disorders - metabolism; Neurons; neurotrophins; Pervasive developmental disorders; Proteins; Receptors, Nerve Growth Factor - genetics; Receptors, Nerve Growth Factor - metabolism; Rodents; Spain; TrkB; Canada; Spain; TrkB; neurodevelopment; BDNF; Rett syndrome; GABAergic neurons; schizophrenia; neurotrophins; autism
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25158312

Neurotrophins and their receptors are distinctly expressed during brain development and play crucial roles in the formation, survival, and function of neurons in the nervous system. Among these molecules, brain-derived neurotrophic factor (BDNF) has garnered significant attention due to its involvement in regulating GABAergic system development and function. In this review, we summarize and compare the expression patterns and roles of neurotrophins and their receptors in both the developing and adult brains of rodents, macaques, and humans. Then, we focus on the implications of BDNF in the development and function of GABAergic neurons from the cortex and the striatum, as both the presence of BDNF single nucleotide polymorphisms and disruptions in BDNF levels alter the excitatory/inhibitory balance in the brain. This imbalance has different implications in the pathogenesis of neurodevelopmental diseases like autism spectrum disorder (ASD), Rett syndrome (RTT), and schizophrenia (SCZ). Altogether, evidence shows that neurotrophins, especially BDNF, are essential for the development, maintenance, and function of the brain, and disruptions in their expression or signaling are common mechanisms in the pathophysiology of brain diseases.