Altered resting-state functional connectivity of the right precuneus and cognition between depressed and non-depressed schizophrenia

• Published in: Psychiatry research. Neuroimaging Vol. 317; p. 111387
• Main Authors: Li, Pingping, Zhou, Min, Yan, Wei, Du, Jinglun, Lu, Shuiping, Xie, Shiping, Zhang, Rongrong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30-11-2021
• Subjects: Brain; Brain Mapping - methods; Cognition; Depressed schizophrenia; Functional connectivity; Humans; Magnetic Resonance Imaging - methods; Parietal Lobe - diagnostic imaging; Resting-state functional MRI; Right precuneus; Schizophrenia - complications; Schizophrenia - diagnostic imaging; Functional connectivity; Cognition; Resting-state functional MRI; Depressed schizophrenia; Right precuneus
• ISSN: 0925-4927; 1872-7506
• DOI: 10.1016/j.pscychresns.2021.111387

•We compared resting-state functional connectivity and cognition between 40 depressed schizophrenia, 40 non-depressed schizophrenia and 50 healthy individuals.•Depressed schizophrenia patients had decreased connectivity between the right precuneus and left middle cingulate gyrus, left cerebellum, right cerebellum.•Depressed schizophrenia patients had increased connectivity between the right precuneus and temporal lobe, occipital lobe.•There were no differences in cognition between depressed and nondepressed patients, but their connectivity changes correlate differently with cognitive impairment.
The study investigated the resting-state functional connectivity (FC) and cognitive changes in patients with depressed schizophrenia(DS) and non-depressed schizophrenia(NDS). Eighty patients with first-episode schizophrenia and 50 healthy controls (HC) were included to conduct resting-state fMRI. All participants completed MATRICS Consensus Cognitive Battery (MCCB). The right precuneus was selected as the seed in whole-brain FC analysis. Our results showed the cognitive function (All MCCB dimensions) of all schizophrenia patients were worse than HC, but no differences were found between DS and NDS. The DS had decreased FC than NDS between the right precuneus and left middle cingulate gyrus, left cerebellum, right cerebellum. The DS had increased FC than HC between the right precuneus and temporal lobe, occipital lobe, and decreased FC between the right precuneus and left cerebellum. However, the NDS had increased FC than HC between the right precuneus and left cerebellum, right cerebellum, temporal lobe, occipital lobe, left superior parietal lobule. Correlation analysis showed that FC between the right precuneus and occipital lobe was negatively correlated with visual learning in DS and with social cognition in NDS. Our results suggest DS and NDS patients have different patterns of FC, and their FC changes correlate with different domains of cognition.