Growth of the conceptus from days 33 to 45 of pregnancy is similar for heifers and lactating cows and not associated with circulating glucose, insulin, IGF1 or progesterone concentrations

• Published in: Animal reproduction science Vol. 216; p. 106463
• Main Authors: Stratman, T.J., Poock, S.E., Moore, S.G., Lucy, M.C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-05-2020
• Subjects: Animals; Blood Glucose; Cattle - embryology; Dairy; Embryo; Embryonic Development - physiology; Female; Fertility; Glucose - metabolism; Insulin - blood; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Lactation; Metabolites; Pregnancy; Progesterone - metabolism; Dairy; Embryo; Metabolites; Fertility
• ISSN: 0378-4320; 1873-2232
• DOI: 10.1016/j.anireprosci.2020.106463

•Growth of the conceptus was similar for cows and heifers.•Hormone/metabolite concentrations were not associated with fetal growth.•Embryonic loss occurred in conceptuses with equal or smaller size.
Less than optimal circulating progesterone as well as glucose, insulin, and IGF1 concentrations in lactating cows may contribute to embryonic loss if placental development is dependent on concentrations of these hormones. There was comparison of fetal growth in lactating dairy cows with a contemporary group of nulliparous heifers (negative control for lactation). There was also assessment of the association between conceptus development and circulating hormone and metabolite concentrations and the response to an intravenous glucose administration. The embryo and amniotic vesicle were measured every 2–3 days during a 2-week period (days 33–45 of pregnancy). Blood samples were collected at the time of ultrasonography and analyzed for glucose, insulin, IGF1, and progesterone. There was also an intravenous glucose administration. Lactating cows had lesser blood concentrations of glucose, progesterone, and IGF1 during pregnancy. With respect to glucose administration, cows had lesser insulin and glucose than heifers at time 0 but heifers released three-fold more insulin than cows in response to glucose infusion. Cows had slightly larger fetuses when compared with heifers. When included in the model for embryo or amniotic vesicle length or area, concentrations of circulating glucose, insulin, IGF1, or progesterone did not explain a large amount of variation in values for these variables (P > 0.10). The conclusion was that cows differed from heifers for fetal growth but concentrations of circulating metabolites were not associated with size of the fetus. There was no evidence for an association between the hormonal or metabolic milieu and conceptus development.