Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American populations

• Published in: Acta tropica Vol. 210; p. 105546
• Main Authors: Strauss, Mariana, Casares-Marfil, Desiré, Alcaraz, Alexia, Palma-Vega, Miriam, Bosch-Nicolau, Pau, Lo Presti, María Silvina, Molina, Israel, González, Clara Isabel, Martín, Javier, Acosta-Herrera, Marialbert
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-10-2020
• Subjects: Adult; Aged; Association study; Chagas Cardiomyopathy - etiology; Chagas Cardiomyopathy - genetics; Chagas disease; Chronic Disease; Female; Genetic Predisposition to Disease; Humans; IL6 polymorphism; Interleukin-6 - genetics; Latin America; Male; Meta-analysis; Middle Aged; Polymorphism, Single Nucleotide; Latin America; Chagas disease; Association study; IL6 polymorphism; Meta-analysis
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/j.actatropica.2020.105546

The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in five independent Latin American cohorts. A total of 3,087 individuals from Latin American countries (Argentina, Bolivia, Peru, and two cohorts from Colombia) were studied. In all cohorts, patients were classified as seropositive for T. cruzi antigens (n= 1,963) and seronegative (n= 1,124). Based on clinical evaluation, the seropositive patients, were classified as CCC (n= 900) and asymptomatic (n= 1,063). No statistically significant differences in the frequency of IL6 rs1800795 between seropositive and seronegative, or between CCC and asymptomatic patients, were found. Furthermore, after the meta-analysis no statistically significant differences were observed. Our results do not support a contribution of IL6 rs1800795 genetic variant in the susceptibility to the infection and the development of chronic Chagas cardiomyopathy in the studied populations.