Diagnostic value of bladder tumor fibronectin in patients with bladder tumor: A systematic review with meta-analysis

• Published in: Clinical biochemistry Vol. 46; no. 15; pp. 1377 - 1382
• Main Authors: Yang, Xiaorong, Huang, Huang, Zeng, Zongyue, Zhao, Liuyang, Hu, Ping, He, Dali, Tang, Xi, Zeng, Zhaofang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-10-2013
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - urine; Bladder tumor; Bladder tumor fibronectin; Case-Control Studies; Databases, Bibliographic; Diagnosis; Early Diagnosis; Female; Fibronectins - urine; Humans; Male; Meta-analysis; Middle Aged; Predictive Value of Tests; ROC Curve; Software; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - urine; Bladder tumor fibronectin; CI; DOR; Bladder tumor; AUC; Meta-analysis; TUR; BTF; NLR; SROC; PLR; Diagnosis; QUADAS; positive likelihood ratio; area under the summary ROC curve; quality assessment of diagnostic accuracy studies; diagnostic odds ratio; negative likelihood ratio; confidence interval; summary receiver operator characteristic; transurethral resection
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2013.05.064

Bladder tumor fibronectin (BTF) has been related as a promising biomarker for the early diagnosis of bladder tumor. The meta-analysis was used to establish the diagnostic value of bladder tumor fibronectin in diagnosing bladder tumor.
Relevant literatures evaluating the value of BTF in the diagnosis of bladder tumor were searched in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Data. Summary estimates were used to evaluate the value of BTF in the diagnosis of bladder tumor by using the Meta-DiSc and STATA 11.0 statistical software.
The meta-analysis included 5 studies (649 patients, 291 controls). The summary estimates revealed that the pooled sensitivity was 81% (95% confidence interval [CI]: 74%–85.1%) and specificity was 80% (95%CI 74%–84%). In addition, the area under the summary ROC curve (AUC) was 0.86 (95%CI 0.82–0.89).
BTF is a potential marker for the diagnosis of bladder tumor, and more prospective studies are needed in the future.
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•Five eligible studies were performed by comprehensive meta-analysis.•Bladder tumor fibronectin appears to be a promising biomarker in urine for bladder tumor.•Bladder tumor fibronectin may be proven to be a rapid and less invasive method in diagnosing bladder tumor.