Use of the reference method for determination of serum calcium in a quality-assurance survey

Use of the reference method for determination of serum calcium in a quality-assurance survey

The Reference Method [Clin. Chem. 19, 1208 (1973)] for determination of total calcium in serum has been applied to 29 specimens from the Wellcome Group Quality-Control Programme. The accuracy of the mean results for all participants, and for selected groups of participants, was determined over the c...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Vol. 21; no. 10; p. 1416
Main Authors: Pickup, J F, Jackson, M J, Price, E M, Healy, M J, Brown, S S
Format: Journal Article
Language:English
Published: England 01-09-1975
Subjects:
Animals
Autoanalysis
Calcium - blood
Edetic Acid
Methods
Quality Control
Spectrophotometry, Atomic
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Summary:The Reference Method [Clin. Chem. 19, 1208 (1973)] for determination of total calcium in serum has been applied to 29 specimens from the Wellcome Group Quality-Control Programme. The accuracy of the mean results for all participants, and for selected groups of participants, was determined over the concentration range 2.00-2.75 mmol/liter. We show that, in general, continuous-flow (AutoAnalyzer) and atomic absorption methods of analysis have a small, constant bias, but chelation (ethylenediaminetetraacetate) methods are unpredictably inaccurate.
ISSN:0009-9147
DOI:10.1093/clinchem/21.10.1416