Introduction to Genetic Processes in Transplantation

Recent investigations have explored how analyses of genetic DNA from organ donors and recipients may be helpful during organ allocation so as to reduce graft rejection or improve dosing of immunosuppressive medications. This discussion reviews those data and the processes by which genetic coding con...

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Bibliographic Details
Published in:	Progress in transplantation (Aliso Viejo, Calif.) Vol. 22; no. 2; pp. 192 - 198
Main Authors:	Santiago-Sim, Teresa, Colosimo, Sarah, Powner, David J.
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-06-2012 SAGE PUBLICATIONS, INC
Subjects:	Genetic Phenomena Genetic Predisposition to Disease Genotype Graft Rejection - genetics Graft Survival - genetics Humans Immunosuppressive Agents - pharmacology Mutation Nursing Transplantation
Online Access:	Get full text
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Summary:	Recent investigations have explored how analyses of genetic DNA from organ donors and recipients may be helpful during organ allocation so as to reduce graft rejection or improve dosing of immunosuppressive medications. This discussion reviews those data and the processes by which genetic coding controls the production of protein that is important in cellular structure and function during donor and recipient care. Changes in gene structure (polymorphisms or mutations) may occur spontaneously or as a result of cell interactions with environmental factors, and may be associated with recognized diseases or, potentially, could reduce or worsen graft rejection.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1526-9248 2164-6708
DOI:	10.7182/pit2012132