Histopathological and molecular links of COVID-19 with novel clinical manifestations for the management of coronavirus-like complications

• Published in: Inflammopharmacology Vol. 30; no. 4; pp. 1219 - 1257
• Main Authors: Sood, Ankita, Bedi, Onkar
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-08-2022
• Subjects: Allergology; Biomedical and Life Sciences; Biomedicine; COVID-19; Dermatology; Gastroenterology; Humans; Immunology; Pandemics; Pharmacology/Toxicology; Review; Rheumatology; SARS-CoV-2; COVID-19; SARS-CoV-2; Histopathology; Pulmonary disorders; Viral infection; Systemic manifestations
• ISSN: 0925-4692; 1568-5608
• DOI: 10.1007/s10787-022-00999-9

Coronavirus disease 2019 (COVID-19) causes transmissible viral illness of the respiratory tract prompted by the SARS-CoV-2 virus. COVID-19 is one of the worst global pandemics affecting a large population worldwide and causing catastrophic loss of life. Patients having pre-existing chronic disorders are more susceptible to contracting this viral infection. This pandemic virus is known to cause notable respiratory pathology. Besides, it can also cause extra-pulmonary manifestations. Multiple extra-pulmonary tissues express the SARS-CoV-2 entry receptor, hence causing direct viral tissue damage. This insightful review gives a brief description of the impact of coronavirus on the pulmonary system, extra-pulmonary systems, histopathology, multiorgan consequences, the possible mechanisms associated with the disease, and various potential therapeutic approaches to tackle the manifestations.