Association between Maternal Birth Weight and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

• Published in: Journal of obstetrics and gynaecology of India Vol. 72; no. 2; pp. 125 - 133
• Main Authors: Shokri, Mehdi, Rizebandi, Mahsa, Karimi, Parviz, Badfar, Gholamreza, Nasirkandy, Marzieh Parizad, Kalvandi, Gholamreza, Rahmati, Shoboo
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01-04-2022
• Subjects: Gynecology; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Systematic Reviews/Meta-analysis; Systematic review; Gestational diabetes; Maternal birth weight; Meta-analysis
• ISSN: 0971-9202; 0975-6434
• DOI: 10.1007/s13224-022-01645-8

s
Background and Aims
Gestational diabetes mellitus is one of the most important issue related to health status of mothers and their children throughout life. This meta-analysis has been conducted to assess relationship between maternal birth weight and gestational diabetes.
Methods and Results
This article is written using PRISMA guideline for systematic review and meta-analysis. We searched epidemiological studies without a time limit from following databases—Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane, EBSCO, and Google Scholar search engine using MESH keywords. Heterogeneity was determined using the Cochran
Q
test and
I
2
index. Data were analyzed using comprehensive meta-analysis, version 2. The significance level of the tests was considered as
P
 < 0.05.
Results
The result of combining ten studies with a sample size of 228,409 cases using a fixed-effect model showed that low maternal birth weight increased the risk of gestational diabetes mellitus (1.71 [95% CI 1.43–2.06,
P
 < 0.001]). In addition, the result of combining nine studies with a sample size of 227,805 cases using a random-effects model showed that macrosomia did not increase the risk of gestational diabetes mellitus, and there was no significant relationship between them (1.04 [95% CI 0.79–1.38;
p
value: 0.730]).
Conclusion
The results of this systematic review and meta-analysis showed that low maternal birth weight could be a risk factor for gestational diabetes in adulthood.