Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates
The concept of inhibiting tumor neovessels has taken the hurdle from the bench to the bedside and now represents an extra pillar of anticancer treatment. So far, anti-angiogenic therapy prolongs survival in the order of months in some settings while failing to induce a survival benefit in others, in...
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| Published in: | Genes & cancer Vol. 1; no. 1; pp. 12 - 25 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
SAGE Publications
01-01-2010
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The concept of inhibiting tumor neovessels has taken the hurdle from the bench to the bedside and now represents an extra pillar of anticancer treatment. So far, anti-angiogenic therapy prolongs survival in the order of months in some settings while failing to induce a survival benefit in others, in part because of intrinsic refractoriness or evasive escape. This review provides an update on recent mechanisms via which tumor and stromal cells induce resistance and discusses recent evolutions in the (pre)clinical development of novel third-generation anti-angiogenic agents to overcome this problem. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 authors contributing equally to this work |
| ISSN: | 1947-6019 1947-6027 |
| DOI: | 10.1177/1947601909356574 |