LISTERIN E3 Ubiquitin Ligase and Ribosome-Associated Quality Control (RQC) Mechanism

• Published in: Molecular neurobiology Vol. 58; no. 12; pp. 6593 - 6609
• Main Authors: Mishra, Ribhav, Bansal, Anurag, Mishra, Amit
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-12-2021; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain - metabolism; Cell Biology; Embryogenesis; Embryonic Development - physiology; Humans; Neurobiology; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Neurology; Neurons - metabolism; Neurosciences; Protein Folding; Protein Isoforms - metabolism; Proteins; Quality control; Ribosomes; Ribosomes - metabolism; RING finger proteins; Spinal cord; Spinal Cord - metabolism; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; LISTERIN; E3 ubiquitin ligase; Neurodegeneration; Misfolded proteins
• ISSN: 0893-7648; 1559-1182; 1559-1182
• DOI: 10.1007/s12035-021-02564-x

According to cellular demands, ribosomes synthesize and maintain the desired pool of proteins inside the cell. However, sometimes due to defects in ribosomal machinery and faulty mRNAs, these nascent polypeptides are constantly under threat to become non-functional. In such conditions, cells acquire the help of ribosome-associated quality control mechanisms (RQC) to eliminate such aberrant nascent proteins. The primary regulator of RQC is RING domain containing LISTERIN E3 ubiquitin ligase, which is associated with ribosomes and alleviates non-stop proteins–associated stress in cells. Mouse RING finger protein E3 ubiquitin ligase LISTERIN is crucial for embryonic development, and a loss in its function causes neurodegeneration. LISTERIN is overexpressed in the mouse brain and spinal cord regions, and its perturbed functions generate neurological and motor deficits, but the mechanism of the same is unclear. Overall, LISTERIN is crucial for brain health and brain development. The present article systematically describes the detailed nature, molecular functions, and cellular physiological characterization of LISTERIN E3 ubiquitin ligase. Improve comprehension of LISTERIN’s neurological roles may uncover pathways linked with neurodegeneration, which in turn might elucidate a promising novel therapeutic intervention against human neurodegenerative diseases.