Relationship Between Zinc, Selenium, and Magnesium Status and Markers of Metabolically Healthy and Unhealthy Obesity Phenotypes

• Published in: Biological trace element research Vol. 202; no. 8; pp. 3449 - 3464
• Main Authors: Cruz, Kyria Jayanne Clímaco, de Oliveira, Ana Raquel Soares, Fontenelle, Larissa Cristina, Morais, Jennifer Beatriz Silva, de Sousa Melo, Stéfany Rodrigues, dos Santos, Loanne Rocha, de Sousa, Thayanne Gabryelle Visgueira, de Freitas, Suelem Torres, Henriques, Gilberto Simeone, Bordin, Silvana, Maia, Carla Soraya Costa, de Oliveira, Francisco Erasmo, Costa, Carlos Henrique Nery, de Matos Neto, Emídio Marques, do Nascimento Marreiro, Dilina
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-08-2024; Springer Nature B.V
• Subjects: Adipose tissue; Adult; Biochemistry; Biomarkers - blood; Biomarkers - urine; Biomedical and Life Sciences; Biotechnology; Body Mass Index; Body size; Body weight; Cross-Sectional Studies; Diet; Dietary intake; Erythrocytes; Female; Food intake; Humans; Life Sciences; Magnesium; Magnesium - blood; Magnesium - urine; Metabolic disorders; Middle Aged; Minerals; Nutrition; Obesity; Obesity - blood; Obesity - urine; Oncology; Parameter estimation; Phenotype; Phenotypes; Selenium; Selenium - blood; Selenium - urine; Thyroid; Zinc; Zinc - blood; Zinc - urine; Metabolically Healthy Obesity; Obesity; Selenium; Magnesium; Zinc
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-023-03938-z

Our objective was to investigate the relationship between zinc, selenium, and magnesium status and markers of metabolically healthy and unhealthy obesity phenotypes. This was a cross-sectional study with 140 women: metabolically healthy obese women (
n
 = 35), metabolically unhealthy obese women (
n
 = 28), and normal-weight women (
n
 = 77). We have calculated the body mass index, waist-hip ratio, waist-height ratio and some adiposity indices. Additionally, we evaluated endocrine-metabolic parameters and estimated the dietary intake of energy, macronutrients, zinc, selenium, and magnesium. The mineral concentrations in plasma, erythrocytes, and urine were assessed. In obese patients, there was a significant decrease in dietary zinc, selenium, and magnesium intake per kilogram of body weight, as well as lower mineral concentrations in both plasma and erythrocytes. Additionally, these patients exhibited higher urinary mineral levels compared to the control group, regardless of whether they had healthy or unhealthy phenotypes. We observed a significant correlation between deficiencies in zinc, selenium, and magnesium and obesity-associated metabolic disorders, including dyslipidemias and redox status disturbances. This study highlights a connection between deficiencies in zinc, selenium, and magnesium and metabolic disorders linked to obesity, including dyslipidemias, alterations in redox status, and thyroid hormonal dysfunction.