Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects

• Published in: International journal of biological macromolecules Vol. 120; no. Pt B; pp. 1682 - 1695
• Main Authors: Bukhari, Syed Nasir Abbas, Roswandi, Nur Liyana, Waqas, Muhammad, Habib, Haroon, Hussain, Fahad, Khan, Shahzeb, Sohail, Muhammad, Ramli, Nor Amlizan, Thu, Hnin Ei, Hussain, Zahid
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-12-2018
• Subjects: Animals; Anti-aging, nasolabial folds, dermal filler; Anti-wrinkle; Cosmetics - pharmacology; Face rejuvenation; Humans; Hyaluronic acid; Hyaluronic Acid - pharmacology; Nutricosmetic; Rejuvenation; Skin - drug effects; Anti-aging, nasolabial folds, dermal filler; Nutricosmetic; Hyaluronic acid; Face rejuvenation; Anti-wrinkle
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2018.09.188

Hyaluronic acid (HA) plays multifaceted role in regulating the various biological processes such as skin repairmen, diagnosis of cancer, wound healing, tissue regeneration, anti-inflammatory, and immunomodulation. Owing to its remarkable biomedical and tissue regeneration potential, HA has been numerously employed as one of the imperative components of the cosmetic and nutricosmetic products. The present review aims to summarize and critically appraise recent developments and clinical investigations on cosmetic and nutricosmetic efficacy of HA for skin rejuvenation. A thorough analysis of the literature revealed that HA based formulations (i.e., gels, creams, intra-dermal filler injections, dermal fillers, facial fillers, autologous fat gels, lotion, serum, and implants, etc.) exhibit remarkable anti-wrinkle, anti-nasolabial fold, anti-aging, space-filling, and face rejuvenating properties. This has been achieved via soft tissue augmentation, improved skin hydration, collagen and elastin stimulation, and face volume restoration. HA, alone or in combination with lidocaine and other co-agents, showed promising efficacy in skin tightness and elasticity, face rejuvenation, improving aesthetic scores, reducing the wrinkle scars, longevity, and tear trough rejuvenation. Our critical analysis evidenced that application/administration of HA exhibits outstanding nutricosmetic efficacy and thus is warranted to be used as a prime component of cosmetic products.
•Hyaluronic acid plays multifaceted role in regulating the various biological processes.•Hyaluronic acid exhibits remarkable skin regenerating and collagen stimulating efficacy.•Intradermal injection of hyaluronic acid showed promising anti-wrinkle, anti-nasolabial folds, and anti-aging effects.•Hyaluronic acid based fillers exhibit strong aesthetic impact on face rejuvenation and restoration of mid-face volume.