Structural and functional brain connectivity in moderate–late preterm infants with low-grade intraventricular hemorrhage

• Published in: Neuroradiology Vol. 64; no. 1; pp. 197 - 204
• Main Authors: Argyropoulou, Maria I., Xydis, Vasileios G., Drougia, Aikaterini, Giantsouli, Anastasia S., Giapros, Vasileios, Astrakas, Loukas G.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2022; Springer Nature B.V
• Subjects: Abnormalities; Babies; Brain; Brain - diagnostic imaging; Brain mapping; Cerebral Hemorrhage - diagnostic imaging; Cognition; Diffusion Tensor Imaging; Functional magnetic resonance imaging; Gestational age; Hemorrhage; Humans; Imaging; Infant; Infant, Newborn; Infant, Premature; Infants; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Modularity; Neonates; Neural networks; Neuroimaging; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Operculum; Paediatric Neuroradiology; Premature babies; Radiology; Structure-function relationships; Tensors; Topology; Graph theory; Brain connectivity; Germinal matrix-intraventricular hemorrhage; MRI; Moderate–late preterm
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s00234-021-02770-3

Purpose
Brain functional connectivity (FC) changes and microstructural abnormalities are reported in infants born moderate and late preterm (MLPT). We evaluated the effect of low-grade (grades I, II) intraventricular hemorrhage (IVH) in MLPT babies on brain structural connectivity (SC) and FC.
Methods
Babies born MLPT between January 2014 and May 2017 underwent brain ultrasound (US) at 72 h and 7 days after birth, and MRI at around term equivalent. The MRI protocol comprised T1- and T2-weighted sequences, diffusion tensor imaging (DTI), and resting-state functional MRI (fMRI). SC and FC were assessed using graph analysis.
Results
Of 350 MLPT neonates, 15 showed low-grade IVH on US at 72 h, for which brain MRI was available in 10. These 10 infants, with mean gestational age (GA) 34.0 ± 0.8 weeks, comprised the study group, and 10 MLPT infants of mean GA 33.9 ± 1.1 weeks, with no abnormalities on brain US and MRI, were control subjects. All study subjects presented modularity, small world topology, and rich club organization for both SC and FC. The patients with low-grade IVH had lower FC rich club coefficient and lower SC betweenness centrality in the left frontoparietal operculum, and lower SC rich club coefficient in the right superior orbitofrontal cortex than the control subjects.
Conclusions
Topological and functional properties of mature brain connectivity are present in MLPT infants. IVH in these infants was associated with structural and functional abnormalities in the left frontoparietal operculum and right orbitofrontal cortex, regions related to language and cognition.