Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway

LncRNAs have been proved to be involved in the promotion of glioma cell malignant development. However, the exact roles and molecular mechanisms of linc01023 in glioma remain blurred. In this study, we confirm linc01023 is up-regulated in glioma tissues and cell lines. In addition, elevated linc0102...

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Bibliographic Details
Published in:	Journal of Cancer Vol. 10; no. 13; pp. 2961 - 2968
Main Authors:	Yu, Mingjun, Yu, Shijia, Gong, Wei, Chen, Duo, Guan, Junhong, Liu, Yunhui
Format:	Journal Article
Language:	English
Published:	Australia Ivyspring International Publisher 01-01-2019
Subjects:	Research Paper AKT Linc01023 Prognosis Glioma IGF1R
Online Access:	Get full text
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Summary:	LncRNAs have been proved to be involved in the promotion of glioma cell malignant development. However, the exact roles and molecular mechanisms of linc01023 in glioma remain blurred. In this study, we confirm linc01023 is up-regulated in glioma tissues and cell lines. In addition, elevated linc01023 expression indicates shorter survival times in patients with glioma. Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. Collectively, the study indicates that linc01023 plays an oncogenic role in glioma through activation of IGF1R/AKT signal pathway, and it could be a candidate therapeutic target.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interest exists.
ISSN:	1837-9664 1837-9664
DOI:	10.7150/jca.31004