In-vitro activity of commonly used antifungal agents in the presence of rifampin, polymyxin B and norfloxacin against Candida albicans

This study assessed the in-vitro antifungal activity against Candida albicans of amphotericin B, ketoconazole and miconazole, each in the presence of rifampin, polymyxin B and norfloxacin. Evaluation of drug interactions was estimated by the checkerboard pattern broth dilution method and by time-kil...

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Bibliographic Details
Published in:	Journal of chemotherapy (Florence) Vol. 7; no. 6; p. 525
Main Author:	Moneib, N A
Format:	Journal Article
Language:	English
Published:	England 01-12-1995
Subjects:	Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antibiotics, Antitubercular - pharmacology Antifungal Agents - pharmacology Candida albicans - drug effects Drug Synergism Drug Therapy, Combination - pharmacology In Vitro Techniques Norfloxacin - pharmacology Polymyxin B - pharmacology Rifampin - pharmacology
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Summary:	This study assessed the in-vitro antifungal activity against Candida albicans of amphotericin B, ketoconazole and miconazole, each in the presence of rifampin, polymyxin B and norfloxacin. Evaluation of drug interactions was estimated by the checkerboard pattern broth dilution method and by time-kill studies. Rifampin reduced the activity of the three antifungal agents used, with the reduction being more pronounced with amphotericin B. Synergy was observed when polymyxin B was combined with any of the antifungal agents used. The addition of norfloxacin resulted in minimal, if any, change in the activity.
ISSN:	1120-009X
DOI:	10.1179/joc.1995.7.6.525