Microvascular and structural alterations in the optic nerve head of advanced primary open-angle glaucoma compared with atrophic non-arteritic anterior ischemic optic neuropathy

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 259; no. 7; pp. 1945 - 1953
• Main Authors: Hondur, Gozde, Sen, Emine, Budakoglu, Ozlem
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2021; Springer Nature B.V
• Subjects: Angiography; Eye; Glaucoma; Ischemia; Medicine; Medicine & Public Health; Microvasculature; Multivariate analysis; Ophthalmology; Optic nerve; Optic neuropathy; Visual field; Vessel density; Non-arteritic anterior ischemic optic neuropathy; Optical coherence tomography angiography; Peripapillary retinal nerve fiber layer thickness; Radial peripapillary capillaries; Primary open-angle glaucoma
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-021-05122-2

Purpose
This cross-sectional study compared the peripapillary vessel density (VD), peripapillary retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters between eyes with atrophic non-arteritic anterior ischemic optic neuropathy (NAION) and eyes with advanced primary open-angle glaucoma (POAG) matched for visual field mean deviation.
Methods
Peripapillary VDs and RNFL thicknesses in the peripapillary region, and 4 sectors (superior, inferior, nasal, and temporal), and scanning laser ophthalmoscopy parameters of the ONH were evaluated with optical coherence tomography angiography (OCTA) among 21 atrophic NAION cases, 26 advanced POAG cases, and 30 age- and sex-matched healthy controls.
Results
The POAG eyes had lower peripapillary VDs in all areas compared with the NAION eyes, which was most marked in the inferior and nasal sectors (
p
=0.005 for both). RNFL loss was similar between the 2 groups in all areas, except for a preserved thickness in the inferior sector in NAION eyes (
p
=0.01). Peripapillary VD demonstrated stronger correlations with global RNFL thickness in the peripapillary region in the NAION eyes compared with that of the POAG eyes (
r
=0.91
p
<0.00001,
r
=0.42
p
=0.03 respectively). In multivariate analysis, the peripapillary VD correlated with age and RNFL thickness in the POAG eyes while it correlated with SSI and RNFL thickness in the NAION eyes.
Conclusions
A tendency for a lower peripapillary VD despite similar visual field mean deviation values may infer a more prominent role of the vascular regression in POAG compared with NAION.