Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report

Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. GLUT12 expression was high in A549 and RH-36; low in HT29;...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of Cancer Vol. 6; no. 2; pp. 139 - 143
Main Authors:	Pujol-Gimenez, Jonai, de Heredia, Fátima Pérez, Idoate, Miguel Angel, Airley, Rachel, Lostao, María Pilar, Evans, Andrew Robert
Format:	Journal Article
Language:	English
Published:	Australia Ivyspring International Publisher 01-01-2015
Subjects:	Short Research Communication Immunohistochemistry Spheroid GLUT12 Glycolytic metabolism Cancer cell lines
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conflict of interest: All authors disclose any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations that could inappropriately influence this work. Both authors have contributed equally to this work.
ISSN:	1837-9664 1837-9664
DOI:	10.7150/jca.10429