Clinical features of simple hemorrhage and myopic choroidal neovascularization associated with lacquer cracks in pathologic myopia

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 258; no. 12; pp. 2661 - 2669
• Main Authors: Ren, Peifang, Lu, Li, Tang, Xuyuan, Lu, Hong, Zhao, Yuan, Lou, Dinghua, Han, Wei
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2020; Springer Nature B.V
• Subjects: Angiography; Atrophy; Fluorescein; Hemorrhage; Medical imaging; Medicine; Medicine & Public Health; Myopia; Ophthalmology; Photography; Retinal Disorders; Vascularization; Choroidal thickness; Pathologic myopia; Simple hemorrhage; Choroidal neovascularization; Lacquer cracks
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-020-04778-6

Purpose
To investigate the clinical features of simple hemorrhage (SH) and myopic choroidal neovascularization (mCNV) lesions in pathologic myopia (PM) accompanied with lacquer cracks (LCs).
Methods
Altogether 105 PM subjects were recruited with fifty-eight eyes categorized as group LC + SH and sixty eyes as group LC + mCNV. LCs were categorized into stellate and linear subtypes. Eye fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography were performed. Clinical demographic data, PM maculopathy, peripapillary atrophy, and macular choroidal thickness (mCT) were documented.
Results
Significant differences in age, gender, BCVA, and PM atrophies were observed between LC + SH and LC + mCNV groups. The stellate LC was more common in elder subjects with more severe chorioretinal atrophy and thinner mCT compared with linear LCs (
P
< 0.05). The mCT in group LC + SH was significantly larger than group LC + CNV (
P
< 0.001), especially in temporal, inferior, and superior locations of macula. The mCT showed correlation with age (
P
< 0.001)with a decreasing rate of 0.696 μm/year.
Conclusions
SH tended to initially occur in younger subjects with linear LCs. mCNV was more common in elder subjects with severe chorioretinal atrophy. Stellate LCs were associated with the worse PM lesions.