Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria

Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria

Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on...

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Bibliographic Details
Published in:AIDS (London) Vol. 35; no. 13; pp. 2225 - 2227
Main Authors: Fajnzylber, Jesse, Sharaf, Radwa, Hutchinson, John N., Aga, Evgenia, Bosch, Ronald J., Hartogensis, Wendy, Jacobson, Jeffrey M., Connick, Elizabeth, Volberding, Paul, Skiest, Daniel J., Margolis, David, Sneller, Michael C., Little, Susan J., Gulick, Roy M., Mellors, John W., Gandhi, Rajesh T., Schooley, Robert T., Henry, Keith, Tebas, Pablo, Deeks, Steve, Chun, Tae-Wook, Collier, Ann C., Hecht, Frederick M., Li, Jonathan Z.
Format: Journal Article
Language:English
Published: Lippincott Williams & Wilkins 01-11-2021
Online Access:Get full text
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Summary:Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-1
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ObjectType-Correspondence-2
ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000002978