Chromosome translocations involving band 7q35 or 7p15 in childhood T-cell leukemia/lymphoma

• Published in: Blood Vol. 72; no. 2; pp. 534 - 538
• Main Authors: KANEKO, Y, MASEKI, N, HOMMA, C, SAKURAI, M, MIZUTANI, S, TAKEDA, T, SHIKANO, T, FUJIMOTO, T, YAOI, K, SHIMOKAWA, T
• Format: Journal Article
• Language: English
• Published: Washington, DC The Americain Society of Hematology 01-08-1988
• Subjects: Adolescent; Biological and medical sciences; Child; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 7; Deltaretrovirus Infections - genetics; Deltaretrovirus Infections - immunology; Female; Genes, Immunoglobulin; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Phenotype; Receptors, Antigen, T-Cell - genetics; Translocation, Genetic; Chromosomal aberration; Human; Molecular hybridization; T cell receptor; Leukemia; Histiogenesis; Hemopathy; Abnormal «C7» chromosome; Lymphoma; C»-Onc gene; T-Lymphocyte; Gene rearrangement; Cytogenetics; Abnormal chromosome; Molecular biology; Child; Chromosome translocation
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.v72.2.534.534

In a chromosome study in childhood T-cell leukemia/lymphoma, we found t(7;11)(q35;p13) in 2 patients, t(7;14) (q35;q11) in one patient, and t(7;14)(p15;q32) in 1 patient. Southern blotting and in situ chromosomal hybridization studies in one patient with the t(7;11) demonstrated that both alleles of the T-cell antigen receptor beta-subunit gene (TCRB) were rearranged, and that one TCRB allele had relocated from 7q35 to the fusion point in band p13 of the involved chromosome 11 (11p-). These findings suggest that juxtaposition of TCRB with the putative oncogene tcl-2 located in band 11p13 may be a critical step toward development of this T-cell leukemia/lymphoma. In the other two translocations, all breakpoints were sites for lymphocyte function genes, ie, 7q35 for TCRB, 14q11 for T-cell antigen receptor alpha-subunit gene (TCRA), 7p15 for T-cell antigen receptor alpha-subunit gene (TCRG), and 14q32 for immunoglobulin heavy-chain gene (IGH). Thus, the findings in these cases allow us to expand the above hypothesis and propose that the juxtaposition of TCRB or TCRG with tcl-2, TCRA, or IGH through chromosomal translocation may activate a mechanism for the genesis of T-cell leukemia/lymphoma with these chromosome translocations.