Musculoskeletal neoplasms: static and dynamic Gd-DTPA--enhanced MR imaging

• Published in: Radiology Vol. 171; no. 3; p. 767
• Main Authors: Erlemann, R, Reiser, M F, Peters, P E, Vasallo, P, Nommensen, B, Kusnierz-Glaz, C R, Ritter, J, Roessner, A
• Format: Journal Article
• Language: English
• Published: United States 01-06-1989
• Subjects: Adipose Tissue - pathology; Adult; Bone Marrow - pathology; Bone Neoplasms - diagnosis; Edema - diagnosis; Female; Gadolinium; Gadolinium DTPA; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Middle Aged; Muscular Diseases - diagnosis; Necrosis - diagnosis; Organometallic Compounds; Pentetic Acid; Prospective Studies; Soft Tissue Neoplasms - diagnosis
• ISSN: 0033-8419
• DOI: 10.1148/radiology.171.3.2717749

Static and dynamic magnetic resonance imaging studies were performed in 69 patients with bone and soft-tissue tumors. T1-weighted spin-echo (SE) imaging after intravenous administration of gadolinium diethylenetriaminepentaacetic acid (DTPA) improved the differentiation of necrotic from viable areas; the contrast-to-noise ratio (C/N) between tumor and muscle was an average of 44% lower compared with that in T2-weighted SE imaging. The C/N between tumor and bone marrow or fatty tissue was 43% and 37% lower, respectively, compared with that in nonenhanced T1-weighted SE imaging. Dynamic changes of signal intensity (SI) after Gd-DTPA enhancement were assessed with fast low-angle shot imaging. Of malignant tumors, 84.1% exhibited slopes higher than 30% per minute; 72% of benign tumors showed slopes lower than 30% per minute. The dynamic technique enabled assessment of the malignant potential of a tumor with some overlap (accuracy, 79.7%). Necrotic areas and peritumorous edema showed significantly lower and more gradual increases in SI than adjacent neoplastic tissue.