Mossy fiber sprouting in the dentate gyrus

• Published in: Epilepsia (Copenhagen) Vol. 51; no. s5; p. 39
• Main Author: Buckmaster, Paul S.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-12-2010; Wiley-Blackwell
• Subjects: Axon reorganization; Biological and medical sciences; Epilepsy; Epileptogenesis; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Inhibition; Intracellular labeling; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Positive feedback; Seizures; Synaptic targets; Mossy fiber; Epileptogenesis; Nervous system diseases; Epilepsy; Central nervous system; Intracellular labeling; Positive feedback; Synaptic targets; Encephalon; Cerebral disorder; Axon reorganization; Dentate gyrus; Convulsion; Feedback; Central nervous system disease; Inhibition; Neurological disorder; Hippocampus; Seizures
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/j.1528-1167.2010.02825.x

Summary
Aberrant sprouting of granule cell axons is a common feature in temporal lobe epilepsy. An increasingly detailed picture of granule cell circuit changes has emerged, but the cause–effect relationship between mossy fiber sprouting and epileptogenesis remains unclear. Recent progress in suppressing mossy fiber sprouting might help address its functional consequences. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado‐Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).