A new direct synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids in the presence of sodium borohydride

A new direct synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids in the presence of sodium borohydride

Cinnamic acids have been prepared in 59–86% yields by a new direct synthesis from aromatic aldehydes and aliphatic carboxylic acids in the presence of sodium borohydride and N-methyl-2-pyrrolidinone (NMP) as solvent, at reflux (185–190°C), for 9–12 hours. Without sodium borohydride, this reaction is...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters Vol. 44; no. 17; pp. 3579 - 3580
Main Authors: Chiriac, Constantin I, Tanasa, Fulga, Onciu, Marioara
Format: Journal Article
Language:English
Published: Elsevier Ltd 21-04-2003
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cinnamic acids have been prepared in 59–86% yields by a new direct synthesis from aromatic aldehydes and aliphatic carboxylic acids in the presence of sodium borohydride and N-methyl-2-pyrrolidinone (NMP) as solvent, at reflux (185–190°C), for 9–12 hours. Without sodium borohydride, this reaction is not possible. A novel approach for synthesis of cinnamic acids in the presence of sodium borohydride, as a very effective alternative to the classical Perkin synthesis is reported.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(03)00529-X