Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

• Published in: Neurochemical research Vol. 22; no. 1; pp. 33 - 36
• Main Authors: KABUTO, H, ASANUMA, M, NISHIBAYASHI, S, IIDA, M, OGAWA, N
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 1997; Springer Nature B.V
• Subjects: Acetylcholine - metabolism; Animals; Biological and medical sciences; Drugs, Chinese Herbal - therapeutic use; Gerbillinae; Hydroxyindoleacetic Acid - metabolism; Ischemia; Ischemic Attack, Transient - drug therapy; Ischemic Attack, Transient - metabolism; Male; Medical sciences; Meriones unguiculatus; Metabolism; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Prosencephalon - blood supply; Receptors, Muscarinic - metabolism; Rodents; Serotonin - metabolism; Time Factors; Asia; China; Nervous system diseases; Rat; Serotonin; Metabolite; Rodentia; Cardiovascular disease; Neuroprotective agent; Cerebral disorder; Vascular disease; Cholinergic receptor; Vertebrata; Chemotherapy; Mammalia; Treatment; Ischemia; Folk medicine; Animal; Central nervous system disease; Muscarinic receptor; Cerebrovascular disease; Brain (vertebrata)
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1023/A:1027369119224

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.