The Effect of the Lacticaseibacillus paracasei BEPC22 and Lactiplantibacillus plantarum BELP53 Combination (BN-202M) on Body Fat Percentage Loss in Overweight Individuals: A Randomized, Double-Blind, Placebo-Controlled Study

• Published in: Nutrients Vol. 16; no. 13; p. 1993
• Main Authors: Kwon, Han-Seul, Kim, Seok-Jin, Shin, Kum-Joo, Kim, Sanghoon, Yun, Jongbok, Bae, Jaewoong, Tak, Hyun-Ji, Lee, Na-Rae, Kim, Hyeong-Jun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-07-2024
• Subjects: Absorptiometry, Photon; Adipose Tissue - metabolism; Adipose tissues; Adult; Body fat; body fat percentage; Body Mass Index; Care and treatment; Composition; Double-Blind Method; Evaluation; Female; Good Manufacturing Practice; Health aspects; Humans; Insulin resistance; Lacticaseibacillus paracasei; Lactiplantibacillus plantarum; Lactobacillus plantarum; Male; Middle Aged; Obesity; Overweight; Probiotics; Probiotics - administration & dosage; South Korea; Lacticaseibacillus paracasei; body fat percentage; overweight; gut microbiota; obesity; Lactiplantibacillus plantarum; probiotics
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16131993

BN-202M is derived from humans and consists of two strains,
BEPC22 and
BELP53. Body fat reduction effect and safety of BN-202M were assessed in overweight participants. A total of 150 participants were randomly assigned to the BN-202M and placebo groups at a 1:1 ratio. Dual-energy X-ray absorptiometry was used to objectively measure body fat. After 12 weeks of oral administration, the body fat percentage (-0.10 ± 1.32% vs. 0.48 ± 1.10%;
= 0.009) and body fat mass (-0.24 ± 1.19 kg vs. 0.23 ± 1.05 kg;
= 0.023) of the BN-202M group decreased significantly compared to those of the placebo group. The body weight (-0.58 kg,
= 0.004) and body mass index (BMI; -0.23,
= 0.003) was found to decrease significantly at 12 weeks in the BN-202M group, but not in the placebo group. Metabolome analysis revealed that β-alanine, 3-aminoisobutyric acid, glutamic acid, and octopamine decreased in the weight-decreased BN-202M post-intake group. In the gut microbiota analysis, Akkermansia showed a statistically significant increase in the BN-202M group post-intake compared to the placebo group. No serious adverse events were observed in either group. These results suggest that BN-202M is safe and effective for reducing body fat and weight.