Solution-phase parallel synthesis of benzoxazines using a polymer-supported carbodiimide

A diverse library of 2-aminobenzoxazines 3 has been synthesized using a two step approach. Addition of anthranilic acids to isocyanates affords ureas 2 that can be cyclized by polymer-supported EDC to give 2-aminobenzoxazines 3. A diverse library of 2-aminobenzoxazines has been synthesized using a t...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 39; no. 12; pp. 1487 - 1488
Main Authors: Buckman, Brad O., Morrissey, Michael M., Mohan, Raju
Format: Journal Article
Language:English
Published: Elsevier Ltd 19-03-1998
Online Access:Get full text
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Summary:A diverse library of 2-aminobenzoxazines 3 has been synthesized using a two step approach. Addition of anthranilic acids to isocyanates affords ureas 2 that can be cyclized by polymer-supported EDC to give 2-aminobenzoxazines 3. A diverse library of 2-aminobenzoxazines has been synthesized using a two step approach. Addition of anthranilic acids to isocyanates affords ureas that are cyclized by polymer-supported EDC.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)00012-4