Asymmetric synthesis of diarylmethylamines: preparation of selective opioid delta receptor ligands

Asymmetric synthesis of diarylmethylamines: preparation of selective opioid delta receptor ligands

Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a/ 2b derived from ( R)/( S)-phenylglycinol or enantioselective reduction of 4-[η 6-chromium tricarbonylbenzoyl] bromobenzene using chiral oxazoborol...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron: asymmetry Vol. 9; no. 22; pp. 3963 - 3966
Main Authors: Delorme, Daniel, Berthelette, Carl, Lavoie, Rico, Roberts, Edward
Format: Journal Article
Language:English
Published: Elsevier Ltd 27-11-1998
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a/ 2b derived from ( R)/( S)-phenylglycinol or enantioselective reduction of 4-[η 6-chromium tricarbonylbenzoyl] bromobenzene using chiral oxazoborolidine followed by amine introduction to furnish optically active diarylmethylamines.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(98)00419-4