Facile transformation of 3,4-disubstituted 2-azetidinones to chiral 5,6-dihydro-2-pyridones

Facile transformation of 3,4-disubstituted 2-azetidinones to chiral 5,6-dihydro-2-pyridones

Chiral 5,6-disubstituted-5,6-dihydro-2(1 H)-pyridones were prepared efficiently from readily accessible 3,4-disubstituted-2-azetidinones having preadjusted substituents and stereochemistry through the reductive ring opening of 2-azetidinones followed by Z-selective installation of acetate moiety and...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 42; no. 20; pp. 3483 - 3486
Main Authors: Lee, Hyeon Kyu, Chun, Jong Soo, Pak, Chwang Siek
Format: Journal Article
Language:English
Published: Elsevier Ltd 14-05-2001
Subjects:
azetidinones
piperidines
pyridones
piperidines
pyridones
azetidinones
Online Access:Get full text
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Summary:Chiral 5,6-disubstituted-5,6-dihydro-2(1 H)-pyridones were prepared efficiently from readily accessible 3,4-disubstituted-2-azetidinones having preadjusted substituents and stereochemistry through the reductive ring opening of 2-azetidinones followed by Z-selective installation of acetate moiety and re-cyclization to 2-pyridones. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)00470-1