Investigation of stochastic fluctuations in the signal formation of microbiosensors

• Published in: Biosensors & bioelectronics Vol. 13; no. 1; pp. 55 - 59
• Main Authors: Arakelian, V.B., Wild, J.R., Simonian, A.L.
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 1998; Elsevier Science
• Subjects: Biological and medical sciences; biosensor; Biosensors; Biotechnology; fluctuations; Fundamental and applied biological sciences. Psychology; Methods. Procedures. Technologies; molecular recognition element; substrate complexes; Various methods and equipments; biosensor; molecular recognition element; fluctuations; substrate complexes; Substrate; Fluctuations; Biosensor; Theoretical study; Molecular complex; Stochastic process; Recognition
• ISSN: 0956-5663; 1873-4235
• DOI: 10.1016/S0956-5663(97)00080-8

With a decrease in the dimensions of microbiosensors, the stochastic variation in the number of substrate complexes with the molecular recognition elements of biosensors (enzymes, receptors, antibodies, etc.) can lead to significant fluctuations in the output signal. In this theoretical analysis, the mean current, as well as its dispersion and correlation functions, are determined.