T-cell-B-cell cooperation

T-cell-B-cell cooperation

The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important...

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Bibliographic Details
Published in:Nature reviews. Immunology Vol. 4; no. 4; pp. 308 - 312
Main Author: Mitchison, N. A
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01-04-2004
Subjects:
Allergies
Animals
Antibodies
Antigen Presentation - immunology
Antigens
B-Lymphocytes - immunology
Bone marrow
Cooperation
Humans
Immune system
Immunology
Kinases
Lymphocyte Cooperation
Lymphocytes
Medical research
T cell receptors
T-Lymphocytes - immunology
Thymus gland
United States > US
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Summary:The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with presentation of antigen by specialized antigen-presenting cells (a discovery made at around the same time), it provided the first and most important example of cooperation between different cell types of the immune system. The discovery of T-cell-B-cell cooperation enhanced our understanding of immunoregulation. In doing so, it laid the foundation for much of contemporary research in basic immunology, as well as present ideas about immunological diseases, ranging from immune deficiency to autoimmunity and allergy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1474-1733
1474-1741
DOI:10.1038/nri1334