Synthesis of All Enantiomerically Pure Diastereomers of Aprepitant

Synthesis of All Enantiomerically Pure Diastereomers of Aprepitant

Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and x-ray crystallographic analysis were achieved.

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Bibliographic Details
Published in:Synthetic communications Vol. 40; no. 15; pp. 2254 - 2268
Main Authors: Gangula, Srinivas, Elati, Chandrashekhar R., Mudunuru, Satish Varma, Nardela, Anitha, Dongamanti, Ashok, Bhattacharya, Apurba, Bandichhor, Rakeshwar
Format: Journal Article
Language:English
Published: Philadelphia Taylor & Francis Group 12-07-2010
Taylor & Francis Ltd
Subjects:
ICH
spectroscopy
stereoisomers
synthesis
X-ray crystallography
Online Access:Get full text
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Description
Summary:Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and x-ray crystallographic analysis were achieved.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910903221084