Cathodic Stripping Voltammetric Determination of Cefaclor in Pharmaceutical Formulations

A sensitive method is described for the determination of cefaclor by cathodic stripping voltammetry at the hanging mercury drop electrode. cefaclor is accumulated at the electrode surface as a mercury salt, which is reduced at −0.67 V. The optimum accumulation potential and accumulation time were +0...

Full description

Saved in:

Bibliographic Details
Published in:	Analytical letters Vol. 32; no. 1; pp. 97 - 109
Main Authors:	Rodrigues, L. N. C., Zanoni, M. V. B., Fogg, A. G.
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA Taylor & Francis Group 01-01-1999 Taylor & Francis
Subjects:	Analysis Biological and medical sciences Cefaclor General pharmacology Hanging Mercury Drop Medical sciences Pharmaceuticals Pharmacology. Drug treatments Stripping voltammetry Antibiotic Cephalosporin derivatives β-Lactams Dosage form Antibacterial agent Hanging drop method Cefaclor Cathodic stripping voltammetry Quantitative analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A sensitive method is described for the determination of cefaclor by cathodic stripping voltammetry at the hanging mercury drop electrode. cefaclor is accumulated at the electrode surface as a mercury salt, which is reduced at −0.67 V. The optimum accumulation potential and accumulation time were +0.15 V and up to 180 s, respectively. Linear calibration graphs were obtained between 3.9 μg.L −1 to 39 μg.L −1 and the limit of determination was evaluated to be 1.9 μg.L −1 . The method was applied successfully to the determination of cefaclor in pharmaceutical formulations.
ISSN:	0003-2719 1532-236X
DOI:	10.1080/00032719908542601