Nucleophilic aromatic substitution on 3-aroyl-2-arylbenzothiophenes. Rapid access to raloxifene and other selective estrogen receptor modulators
Versatile, mild and high yielding methods for nucleophilic aromatic substitution of 2-dialkylamino-1-ethoxides and related nucleophiles on 3-aroyl-2-arylbenzothiophene nuclei are presented. A short synthesis of raloxifene is detailed. Nucleophilic aromatic substitution of alkoxyethyldialkylamines an...
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| Published in: | Tetrahedron letters Vol. 40; no. 4; pp. 675 - 678 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
01-01-1999
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| Online Access: | Get full text |
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