Nucleophilic aromatic substitution on 3-aroyl-2-arylbenzothiophenes. Rapid access to raloxifene and other selective estrogen receptor modulators

Nucleophilic aromatic substitution on 3-aroyl-2-arylbenzothiophenes. Rapid access to raloxifene and other selective estrogen receptor modulators

Versatile, mild and high yielding methods for nucleophilic aromatic substitution of 2-dialkylamino-1-ethoxides and related nucleophiles on 3-aroyl-2-arylbenzothiophene nuclei are presented. A short synthesis of raloxifene is detailed. Nucleophilic aromatic substitution of alkoxyethyldialkylamines an...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 40; no. 4; pp. 675 - 678
Main Authors: Schmid, Christopher R., Sluka, James P., Duke, Kristin M.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-01-1999
Online Access:Get full text
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Summary:Versatile, mild and high yielding methods for nucleophilic aromatic substitution of 2-dialkylamino-1-ethoxides and related nucleophiles on 3-aroyl-2-arylbenzothiophene nuclei are presented. A short synthesis of raloxifene is detailed. Nucleophilic aromatic substitution of alkoxyethyldialkylamines and other nucleophiles on 3-aroyl-2-arylbenzothiophenes are presented.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)02533-7