Camptothecin-related alkaloids from hairy roots of Ophiorrhiza pumila

• Published in: Tetrahedron Vol. 58; no. 45; pp. 9169 - 9178
• Main Authors: Kitajima, Mariko, Yoshida, Satoshi, Yamagata, Kyoko, Nakamura, Mio, Takayama, Hiromitsu, Saito, Kazuki, Seki, Hiroko, Aimi, Norio
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 04-11-2002
• Subjects: alkaloids; camptothecin; Ophiorrhiza pumila; camptothecin; Ophiorrhiza pumila; alkaloids
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/S0040-4020(02)01196-1

Hairy roots of
Ophiorrhiza pumila, a rubiaceous camptothecin-producing plant, were obtained. From an investigation of the secondary metabolites, it was found that the hairy roots produced camptothecin and its related alkaloids, i.e. (3
S)-pumiloside, (3
S)- and (3
R)-deoxypumilosides and strictosamide. We also isolated two new camptothecinoids, OPHR-23 and OPHR-17, the structures of which including the absolute configurations, were determined by spectroscopic analyses and chemical conversion from tryptamine and secologanin.
From the hairy roots of
Ophiorrhiza pumila, a rubiaceous camptothecin-producing plant, camptothecin and its related alkaloids including two new camptothecinoids, OPHR-23 and OPHR-17, were isolated. The structures of the new alkaloids including the absolute configurations were determined by spectroscopic analyses and chemical conversion from tryptamine and secologanin.