Dose characteristics of radachlorin photosensitizer in modeling the photodynamic effect on the cellular level

• Published in: Measurement techniques Vol. 54; no. 12; pp. 1412 - 1420
• Main Authors: Zhorina, L. V., Zalevskaya, L. I., Zalevskaya, O. I., Zmievskoi, G. N., Semchuk, I. P., Filatov, V. V.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-03-2012; Springer; Springer Nature B.V
• Subjects: Analytical Chemistry; Aqueous solutions; Blood substitutes; Cellular; Cellular biology; Characterization and Evaluation of Materials; Chlorophyll; Coherence; Dosimetry; Erythrocytes; Experiments; Irradiation; Lasers; Light; Light sources; Light-emitting diodes; Measurement Science and Instrumentation; Measurement techniques; Medical research; Photodynamic therapy; Physical Chemistry; Physics; Physics and Astronomy; Sensors; Studies; effectiveness; pulse regime; Radachlorin; photodynamic effect; threshold dose
• ISSN: 0543-1972; 1573-8906
• DOI: 10.1007/s11018-012-9904-3

A study was carried out on the dose characteristics of the Radachlorin photosensitizer using both a laser light source and partially coherent irradiation from a matrix light-emitting diode observing the photodynamic effect on an erythrocyte suspension at various concentrations. The use of these results is proposed for developing a procedure for the a priori determination of irradiation dose for specific patients in the course of photodynamic therapy.