Candida albicans adherence to resin-composite restorative dental material: Influence of whole human saliva

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 94; no. 5; pp. 589 - 592
• Main Authors: Maza, José Luis, Elguezabal, Natalia, Prado, Carlota, Ellacuría, Joseba, Soler, Iñaki, Pontón, José
• Format: Journal Article
• Language: English
• Published: St. Louis, MO Mosby, Inc 01-11-2002; Elsevier
• Subjects: Analysis of Variance; Biological and medical sciences; Candida albicans - physiology; Cell Adhesion; Composite Resins; Dental Restoration, Permanent; Dentistry; Ent and stomatology; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Humans; Medical sciences; Non tumoral diseases; Otorhinolaryngology. Stomatology; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Resin Cements; Saliva - physiology; Stomatology; Candida albicans; Human; Mycosis; Stomatology; Prosthesis; Dental disease; Instrumentation; Composite material; Fungi; Infection; Treatment; Complication; Influence; Fungi Imperfecti; Resins; Saliva; Colonization; Thallophyta
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1067/moe.2002.126024

Objective. Attachment of Candida albicans to oral surfaces is believed to be a critical event in the colonization of the oral cavity and in the development of oral diseases such as Candida-associated denture stomatitis. Although there is considerable information about the adhesion of C albicans to buccal epithelial cells and prosthetic materials, there is very little information about the adhesion of C albicans to composite restorative materials. The purpose of this study was to investigate the degree of adhesion of C albicans to a resin-composite restorative material (Herculite). Methods. The adhesion of 2 strains of C albicans, a germinative and a germ tube-deficient mutant, was studied by a visual method after incubating the fungus and the resin with and without human whole saliva. Results. In absence of saliva, the adhesion of the C albicans germinative isolate to the resin showed an increase in parallel with the germination, reaching a maximum at the end of the experiment (120 minutes). However, no significant differences were observed in the adhesion of the agerminative mutant during the period of time studied. In the presence of saliva, the adhesion of both isolates to the resin was significantly lowered. Conclusion. Germination and the presence of human whole saliva are important factors in the adhesion of C albicans to the resin-composite restorative material Herculite. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:589-92)