Chaotropic Effect Stabilized Radical‐Containing Supramolecular Organic Frameworks for Photothermal Therapy

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 18; no. 15; pp. e2108055 - n/a
• Main Authors: Li, Wen‐Zhen, Chen, Hao, Shen, Meng‐Na, Yang, Ziqiong, Fan, Zhengyu, Xiao, Ju, Chen, Junling, Zhang, Haibo, Wang, Zhengxi, Wang, Xiao‐Qiang
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01-04-2022
• Subjects: Antiinfectives and antibacterials; Aqueous solutions; Assembly; Biomedical materials; Catalysis; chaotropic effects; dodecaborate clusters; Electron paramagnetic resonance; Frame structures; Functional materials; Light irradiation; Nanotechnology; Photoluminescence; Photothermal Therapy; radical‐containing frameworks; Structural stability; supramolecular organic frameworks; chaotropic effects; supramolecular organic frameworks; dodecaborate clusters; radical-containing frameworks; photothermal therapy
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.202108055

Radical‐containing frameworks (RCFs) have emerged as promising functional materials in various fields due to the combination of the highly ordered frame structure and the fascinating property of organic radicals. Here, the first example of radical‐containing supramolecular organic frameworks (SOFs) fabricated by the chaotropic effect between closo‐dodecaborate cluster (B12H122−) and 2,4,6‐tri(4‐pyridyl)‐1,3,5‐triazine (TPT3+) is presented. The SOFs can be easily synthesized by stirring the B12H122− and the TPT3+ in aqueous solution through self‐assembly. Upon 435 nm light irradiation, the SOFs exhibits photochromic behavior from slight yellow (SOF‐1) to dark purple (SOF‐2). Electron paramagnetic resonance spectroscopy also reveals that stable radicals are generated in situ after light irradiation. Powder X‐ray diffraction demonstrates the SOFs maintain their structural stabilities upon light irradiation. More interestingly, the radical‐containing SOFs exhibit efficient photothermal effect under 660 nm light irradiation, which can be applied as photothermal agent for antibacterial application both in vitro and in vivo. This work highlights the construction of RCFs through supramolecular self‐assembly, which may arouse applications in energy, catalysis, photoluminescence, and biomedical fields.
Radical‐containing supramolecular organic frameworks (SOFs) can be easily synthesized by the chaotropic effect of closo‐dodecaborate cluster and 2,4,6‐tri(4‐pyridyl)‐1,3,5‐triazine. The SOFs exhibit photochromic behavior under 435 nm light irradiation, while showing photothermal effect under 660 nm light irradiation. The radical‐containing SOFs can be applied as effective photothermal antibacterial agent in vitro and in vivo.