Relevance of microRNA 21 in Different Types of Hypertension

• Published in: Current hypertension reports Vol. 19; no. 7; p. 57
• Main Authors: Sekar, Durairaj, Shilpa, B. R., Das, Anupam J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2017; Springer Nature B.V
• Subjects: Animals; Biomarkers - blood; Cardiology; Family Medicine; General Practice; Humans; Hypertension; Hypertension - blood; Hypertension - genetics; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - genetics; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Nephrology; Primary Care Medicine; Resistant Hypertension (E Pimenta; Section Editor; Topical Collection on Resistant Hypertension; Up-Regulation; Hypertension; microRNA; Biomarker; miR-21; Diagnosis
• ISSN: 1522-6417; 1534-3111
• DOI: 10.1007/s11906-017-0752-z

Hypertension (HTN) is a chronic medical condition that commonly affects the aging population worldwide. The prevalence of HTN is increasing in developing countries and is one of the leading causes of death in older individuals. HTN results from a complex interplay of genetic and environmental factors. Besides, HTN can result in various other health complications such as stroke and chronic kidney diseases, if not treated. Although various studies have explained the underlying mechanisms in the pathogenesis of HTN, limited information is available on their biomarkers. MicroRNAs (miRNAs) are RNA molecules that have been recognized as key regulators for HTN. miR-21 is a common microRNA that is has been reported to be significantly upregulated in HTN individuals. Hence, miR-21 can be a potential therapeutic target for HTN. The number of studies related to miR-21 on hypertension is limited. Therefore, the main thrust of this paper is to provide an overview of the current clinical evidence and significance of miR-21 in HTN.