Metastatic Behavior of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy: Association with Primary Tumor Location

• Published in: Annals of surgical oncology Vol. 21; no. 3; pp. 1038 - 1045
• Main Authors: Tanaka, Nobuyuki, Kikuchi, Eiji, Kanao, Kent, Matsumoto, Kazuhiro, Kobayashi, Hiroaki, Ide, Hiroki, Miyazaki, Yasumasa, Obata, Jun, Hoshino, Katsura, Shirotake, Suguru, Akita, Hirotaka, Kosaka, Takeo, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Hasegawa, Shintaro, Nakajima, Yosuke, Jinzaki, Masahiro, Oya, Mototsugu
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-03-2014; Springer Nature B.V
• Subjects: Aged; Female; Follow-Up Studies; Humans; Kidney Neoplasms - etiology; Kidney Neoplasms - secondary; Kidney Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - surgery; Neoplasm Staging; Neoplasms - complications; Neoplasms - pathology; Neoplasms - surgery; Nephrectomy - adverse effects; Oncology; Pelvic Neoplasms - etiology; Pelvic Neoplasms - secondary; Pelvic Neoplasms - surgery; Postoperative Complications - etiology; Prognosis; Retrospective Studies; Surgery; Surgical Oncology; Survival Rate; Ureteral Neoplasms - etiology; Ureteral Neoplasms - secondary; Ureteral Neoplasms - surgery; Urologic Oncology; Urologic Surgical Procedures - adverse effects; Local Recurrence; Pelvic Cavity; Renal Pelvis; Radical Cystectomy; Distant Recurrence
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-013-3349-z

Purpose
To investigate the site-specific pattern of disease recurrence and/or metastasis and the associated patient outcomes after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC).
Methods
A total of 733 patients with UTUC from a retrospective multi-institutional cohort were included, with a median follow-up of 34 months. Associated patient outcomes were analyzed by multivariate analysis. To evaluate the influence of primary tumor location, we divided it into four areas: renal pelvis, and upper, middle, and lower ureter.
Results
A total of 218 patients experienced disease recurrence, with the majority of relapses occurring within the first 3 years. Cumulative incidence rates of first disease recurrence at 1 and 3 years were 18.9 and 29.8 %, respectively. Of these patients, 38.5 % developed distant recurrence; 17.4 % experienced both local and distant recurrences; and 44.0 % developed isolated local recurrence. The predominant sites of distant metastasis were lung, liver, and bone. Multivariate analysis revealed that the prevalence of local recurrence and lung metastasis was significantly associated, with primary tumor location being independent of other clinicopathological variables. Lower/middle ureter tumors had a higher rate of local recurrence in the pelvic cavity, and renal pelvic tumors had a higher prevalence of distant relapse in the lungs. Similar results were obtained when rerunning the data set by excluding patients who received adjuvant chemotherapy (
n
 = 131).
Conclusions
This multi-institutional study provided a detailed picture of metastatic behavior after RNU, and primary tumor locations were associated with unique patterns of metastatic spread in UTUC patients.