20S proteasome in the blood plasma of boys with cryptorchidism

• Published in: Journal of endocrinological investigation Vol. 41; no. 9; pp. 1103 - 1106
• Main Authors: Toliczenko-Bernatowicz, D., Matuszczak, E., Tylicka, M., Sankiewicz, A., Komarowska, M., Gorodkiewicz, E., Debek, W., Hermanowicz, A.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-09-2018; Springer Nature B.V
• Subjects: Antiretroviral drugs; Apoptosis; Apoptosis - physiology; Biomarkers - blood; Blood; Child, Preschool; Cryptorchidism; Cryptorchidism - blood; Cryptorchidism - diagnosis; Cryptorchidism - surgery; Endocrinology; Germ cells; Hernia; Humans; Infant; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Plasma; Proteasome Endopeptidase Complex - blood; Proteasomes; Rapid Communication; Statistical analysis; Surface plasmon resonance; Boys; Cryptorchidism; SPR imaging; Proteasome
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-018-0851-y

Purpose
To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism.
Methods
Patients—50 boys aged 1–4 years (median = 2.4 years) with unilateral cryptorchidism. The control group—50 healthy, age-matched boys (aged 1–4 years, median = 2.1 years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging.
Results
The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2.5-fold higher than in boys with inguinal hernia. We noticed statistically significant difference between 20S proteasome levels in boys with cryptorchidism up to 2 years old and above 2 years old.
Conclusions
We believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells.