Body mass index is independently associated with xanthine oxidase activity in overweight/obese population

• Published in: Eating and weight disorders Vol. 25; no. 1; pp. 9 - 15
• Main Authors: Klisic, Aleksandra, Kocic, Gordana, Kavaric, Nebojsa, Jovanovic, Milovan, Stanisic, Verica, Ninic, Ana
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-02-2020; Springer Nature B.V
• Subjects: Anorexia; Biochemistry; Biomarkers; Blood pressure; Body mass index; Bulimia; Cholesterol; Dehydrogenases; Disease; Enzymes; Inflammation; Medicine; Medicine & Public Health; Obesity; Original Article; Oxidative stress; Population; Primary care; Psychiatry; Regression analysis; Studies; Uric acid; Obesity; Oxidative stress; Xanthine oxidase; Inflammation
• ISSN: 1590-1262; 1124-4909; 1590-1262
• DOI: 10.1007/s40519-018-0490-5

Purpose
The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity.
Methods
A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained.
Results
Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241,
p
 = 0.012) and XDH (beta = − 0.489,
p
 < 0.001) are the independent predictors of XO activity (
R
2
-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction.
Conclusion
Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population.
Level of Evidence
Level V: cross-sectional descriptive study.