Influence of radiographic contrast agents on quantitative coronary angiography

• Published in: Cardiovascular and interventional radiology Vol. 20; no. 1; pp. 5 - 9
• Main Authors: JOST, S, HAUSMANN, D, LIPPOLT, P, GERHARDT, U, LICHTLEN, P. R
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Heidelberg Springer 01-01-1997; Berlin Springer Nature B.V
• Subjects: Aged; Angiography; Angioplasty; Arteries; Biological and medical sciences; BIOMEDICAL RADIOGRAPHY; Cardiovascular disease; Contrast agents; Contrast media; Contrast media. Radiopharmaceuticals; CORONARIES; Coronary Angiography - methods; Coronary artery disease; Coronary Circulation - drug effects; Coronary Disease - diagnostic imaging; Diatrizoate; Heart diseases; Humans; INJECTION; Intervals; IOPAMIDOL; Male; Medical imaging; Medical sciences; Middle Aged; PATIENTS; Pharmacology. Drug treatments; RADIOLOGY AND NUCLEAR MEDICINE; VASCULAR DISEASES; Vascular Resistance - drug effects; VASODILATION; Human; Radiodiagnosis; Exploration; Iopamidol; Coronary arteriography; Hemodynamics; Iodine Organic compounds; Contrast media; Vasodilation; Quantitative analysis
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s002709900101

Quantitative angiographic studies on the vasomotility of epicardial coronary arteries are gaining increasing relevance. We investigated whether radiographic contrast agents might influence coronary vasomotor tone and thereby the results of such studies.
Coronary angiograms were taken in 12 patients with coronary artery disease at intervals of 5, 3, 2, and 1 min with the low-osmolar, nonionic contrast agent iopamidol 300, and were repeated at identical intervals with the high-osmolar, ionic agent diatrizoate 76%.
Quantitative cine film analysis demonstrated no significant diameter changes in angiographically normal and stenotic coronary arteries with iopamidol. With diatrizoate, however, normal segments were dilated 2% +/- 2% (p < 0.01) after 2 min and 10% +/- 3% after the 1 min interval (p < 0.001). Stenoses showed no uniform responses to diatrizoate.
Low-osmolar, nonionic contrast agents should be preferred for quantitative angiographic studies on epicardial coronary vasomotility. When using ionic contrast agents, injection intervals of at least 3 min are required.