TT virus infection: role of interferons, interleukin-28 and 29, cytokines and antiviral proteins

In 1997 a novel virus in the serum of a patient with acute post-transfusion hepatitis of non A-G etiology was identified. This agent was designed TT virus (TTV). It produces persistent viremia and no disease, but the mechanism of its persistence is poorly understood. In the present study mRNA expres...

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Bibliographic Details
Published in:	International journal of immunopathology and pharmacology Vol. 20; no. 2; p. 249
Main Authors:	Garbuglia, A R, Grasso, F, Donà, M G, Mochi, S, Conti, P, De Lutiis, M A, Giorgi, C, Iezzi, T
Format:	Journal Article
Language:	English
Published:	England 01-04-2007
Subjects:	Cell Line, Tumor Cells, Cultured Cytokines - physiology DNA Virus Infections - immunology DNA Virus Infections - pathology DNA Virus Infections - virology Humans Interferons Interleukins - physiology Torque teno virus - immunology
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Summary:	In 1997 a novel virus in the serum of a patient with acute post-transfusion hepatitis of non A-G etiology was identified. This agent was designed TT virus (TTV). It produces persistent viremia and no disease, but the mechanism of its persistence is poorly understood. In the present study mRNA expression of antiviral proteins as MxA, 2' 5' OAS, anti-apopotic protein, cytokines IL- 28, IL- 29 and IFN are examined in a subject affected by B lymphoma and positive for TTV DNA and RNA in this cellular subset, and in BJAB and Dohh2 cell lines.
ISSN:	0394-6320
DOI:	10.1177/039463200702000205