Positive Mitsuda lepromin reactions in long-term treated lepromatous leprosy

Twenty-four lepromatous (LL) patients, treated for 22 to 40 years with chemotherapy, including sulphones and with multidrug therapy, were tested with standard Wade-Mitsuda lepromin. Thirteen gave weak positive (3-4 mm) Mitsuda reactions, confirmed histologically in the ten whose reactions were biops...

Full description

Saved in:

Bibliographic Details
Published in:	Leprosy review Vol. 61; no. 4; p. 347
Main Authors:	Waters, M F, Ridley, D S, Lucas, S B
Format:	Journal Article
Language:	English
Published:	England 01-12-1990
Subjects:	Humans Lepromin - immunology Leprosy, Lepromatous - drug therapy Leprosy, Lepromatous - immunology Time Factors Tuberculin - immunology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Twenty-four lepromatous (LL) patients, treated for 22 to 40 years with chemotherapy, including sulphones and with multidrug therapy, were tested with standard Wade-Mitsuda lepromin. Thirteen gave weak positive (3-4 mm) Mitsuda reactions, confirmed histologically in the ten whose reactions were biopsied. Six of the eleven negative reactors were partly accounted for by a history of relapse, and two others had probably taken dapsone irregularly. Eleven control LL patients, treated for less than 20 years, were uniformly lepromin negative. Spontaneous lepromin conversion appears to occur around 24 years after commencing successful chemotherapy. The late Mitsuda conversions are attributed to delayed clearance of the reservoir of bacterial antigen, but a poor correlation between Mitsuda and Fernandez positivity is not explained.
ISSN:	0305-7518
DOI:	10.5935/0305-7518.19900032