Expression Profiles of Genes—Potential Therapy Targets—and Their Relationship to Survival in Renal Cell Carcinoma

• Published in: Doklady. Biochemistry and biophysics Vol. 478; no. 1; pp. 14 - 17
• Main Authors: Apanovich, N. V., Peters, M. V., Apanovich, P. V., Kamolov, B. Sh, Matveev, V. B., Ginter, E. K., Karpukhin, A. V.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2018; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Cell survival; Clear cell-type renal cell carcinoma; Gene expression; Kidney cancer; Life Sciences; Molecular Biology; Raf protein; Signal transduction; TOR protein; Tumors
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672918010040

The main mechanisms of pathogenesis of clear cell renal cell carcinoma (CCRCC) are realized through the PI3K–AKT–mTOR and Ras–RAF–ERK signaling pathways. Targeted therapy is directed primarily at the genes and their encoded products that are components of these pathways. The levels of expression and coexpression of target genes were determined, and the difference in the functioning of the genes of one of the two major signaling pathways in tumors of CCRCC patients with different life duration (more and less than 3.5 years) and the relationship of the
VEGFA
gene expression level with the life duration was revealed.